Sarepta Therapeutics, Inc., a commercial-stage biopharmaceutical company, focuses on the discovery and development of RNA-targeted therapeutics, siRNA platform, gene therapy, and other genetic therapeutic modalities for the treatment of rare diseases. It offers EXONDYS 51 for the treatment of Duchenne in patients who have a confirmed mutation of the dystrophin gene that is amenable to exon 51 skipping; VYONDYS 53 for the treatment of Duchenne in patients who have a confirmed mutation of the dystrophin gene that is amenable to exon 53 skipping; AMONDYS 45 for the treatment of Duchenne in patients who have a confirmed mutation of the dystrophin gene that is amenable to exon 45 skipping; and ELEVIDYS, an AAV-based gene therapy, which is contraindicated in patients with any deletion in exon 8 and/or exon 9 in the Duchenne gene. The company also develops SRP-9003, a gene therapy program for the treatment of LGMD2E; SRP-1001 to selectively target and knockdown DUX4 using RNAi in Phase 1/2a clinical trials; and SRP-1003 for reduction of expression of the DMPK gene in Phase 1/2a clinical trials. It has collaboration and license agreements with F. Hoffman-La Roche Ltd; Arrowhead Pharmaceuticals, Inc.; University of Western Australia; Nationwide Children’s Hospital; Hansa Biopharma; and Duke University. The company was incorporated in 1980 and is headquartered in Cambridge, Massachusetts.
Competitive Dynamics | Learn how Sarepta navigates emerging competition in gene therapies and exon-skipping treatments, while leveraging its market leadership to maintain dominance in DMD treatment. |
Pipeline Potential | Delve into Sarepta's diverse pipeline, including therapies for limb-girdle muscular dystrophy. Strategic partnerships and expanded indications for Elevidys could drive future growth. |
Financial Crossroads | Explore Sarepta's financial landscape: $2.48B trailing revenue, negative cash flow, and projected sales growth to $4.1B by 2026. Analyst price targets range from $18 to $210. |
Gene Therapy Pionee | Sarepta Therapeutics leads in DMD treatments, with Elevidys at the forefront. Recent safety concerns pose challenges, but the company maintains a strong market position. |

Metrics to compare | SRPT | Sector Sector - Average of metrics from a broad group of related Healthcare sector companies | Relationship RelationshipSRPTPeersSector | |
|---|---|---|---|---|
P/E Ratio | −3.2x | −3.6x | −0.4x | |
PEG Ratio | 0.01 | −0.15 | 0.00 | |
Price / Book | 2.0x | 1.3x | 2.6x | |
Price / LTM Sales | 1.0x | 5.9x | 3.1x | |
Upside (Analyst Target) | −2.3% | 17.3% | 58.8% | |
Fair Value Upside | Unlock | −0.6% | 9.2% | Unlock |