Arrowhead Pharmaceuticals, Inc. develops medicines for the treatment of intractable diseases in the United States. The company’s product pipeline includes Plozasiran, which has completed Phase 3 clinical trial to treat hypertriglyceridemia, dyslipidemia, and familial chylomicronemia syndrome; Olpasiran that is in Phase 3 clinical trial to reduce the production of apolipoprotein A; and Fazirsiran that is in Phase 3 clinical trial for the treatment of liver disease associated with alpha-1 antitrypsin deficiency. It also develops Zodasiran that is in Phase 2b clinical trial for the treatment of dyslipidemia and hypertriglyceridemia; GSK-4532990 to treat metabolic-dysfunction associated steatohepatitis (MASH); and Daplusiran/Tomligisiran which is in Phase 2 clinical trial for the treatment of Chronic Hepatitis B. In addition, the company is developing ARO-PNPLA3, which is in Phase 1 clinical trial to treat patients with MASH; ARO-INHBE to reduce the hepatic expression of the INHBE gene and its secreted gene product; ARO-RAGE to treat inflammatory lung disease; ARO-MUC5AC to treat muco-obstructive pulmonary diseases; and ARO-MMP7 for the treatment of idiopathic pulmonary fibrosis that is in Phase 1/2a clinical trials. Further, it develops ARO-DUX4 for the treatment of facioscapulohumeral muscular dystrophy; ARO-DM1 to treat patient with Type 1 Myotonic Dystrophy; ARO-C3 to treat complement-mediated renal disease; ARO-CFB for the treatment of complement-mediated kidney disease that is in Phase 1/2a clinical trial; and ARO-ATXN2 for the treatment of Spinocerebellar Ataxia Type 2 that is in Phase 1 clinical trial. Arrowhead Pharmaceuticals, Inc. has collaboration and license Agreements with Glaxosmithkline Intellectual Property (No. 3) Limited; Horizon Therapeutics Ireland DAC; Takeda Pharmaceutical Company Limited; and with Amgen Inc. The company was founded in 2003 and is headquartered in Pasadena, California.
Future Horizons | Delve into Arrowhead's innovative integrin-targeting approach, potentially expanding applications in muscle-related disorders and differentiating from competitors |
Market Valuation | Despite pipeline progress, stock underperforms biotech index. Analysts view current price as attractive, with targets ranging from $42 to $73 |
Strategic Pivot | Explore Arrowhead's shift towards cardio-metabolic treatments, allocating 75% of R&D spending to this promising area |
Plozasiran's Promise | Arrowhead's lead drug candidate for FCS treatment nears potential FDA approval, showcasing strong Phase 3 results and advantages over competitors |
Metrics to compare | ARWR | Sector Sector - Average of metrics from a broad group of related Healthcare sector companies | Relationship RelationshipARWRPeersSector | |
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P/E Ratio | −15.6x | −9.3x | −0.5x | |
PEG Ratio | −0.21 | −0.01 | 0.00 | |
Price / Book | 3.3x | 1.2x | 2.6x | |
Price / LTM Sales | 4.1x | 7.4x | 3.0x | |
Upside (Analyst Target) | 144.9% | 192.4% | 52.7% | |
Fair Value Upside | Unlock | 13.7% | 7.6% | Unlock |