MacroGenics, Inc., a clinical-stage biopharmaceutical company, discovers, develops, manufactures, and commercializes antibody-based therapeutics to treat cancer in the United States. The company’s product pipeline includes lorigerlimab, a bispecific DART molecule that targets checkpoint inhibitors PD-1 and CTLA-4 for the treatment of mCRPC and docetaxel that is in phase 2 clinical trials, as well as for the treatment of platinum-resistant ovarian cancer and clear cell gynecologic cancer which has completed phase 1 clinical trial; MGC026, an ADC that targets B7-H3 and delivers a novel topoisomerase I inhibitor (TOP1i)-based linker-payload; MGC028, an antibody-drug conjugates (ADC) that targets ADAM9 and delivers a novel TOP1i-based linker-payload for the treatment of solid tumors, which is in phase 1 clinical trials; MGC030, a ADC molecule for the treatment of solid tumors, which is in preclinical trials. It is also developing next generation T-cell engager programs. The company has collaborations with TerSera Therapeutics LLC; Incyte Corporation; and Gilead Sciences, Inc. MacroGenics, Inc. was incorporated in 2000 and is headquartered in Rockville, Maryland.
Catalysts Ahead | Delve into MacroGenics' near-term growth opportunities, including lorigerlimab Phase 2 data expected in H2 2025 and the initiation of B7-H3 TOP1 ADC Phase 1 expansion. |
Valuation Gap | Trading at approximately 50% discount to projected cash position with analyst price targets around $3, reflecting market uncertainty despite extended financial runway. |
Financial Fortification | A strategic $70M royalty agreement with Sagard extends MacroGenics' runway through 2027, while maintaining eligibility for up to $540M in milestone payments from Incyte partnership. |
Pipeline Pivot | MacroGenics repositions its clinical strategy after discontinuing LORIKEET trial, focusing resources on LINNET trial for platinum-resistant ovarian cancer as a key value driver. |
Metrics to compare | MGNX | Sector Sector - Average of metrics from a broad group of related Healthcare sector companies | Relationship RelationshipMGNXPeersSector | |
|---|---|---|---|---|
P/E Ratio | −1.5x | −0.6x | −0.6x | |
PEG Ratio | −0.07 | 0.07 | 0.00 | |
Price / Book | 1.7x | 2.4x | 2.6x | |
Price / LTM Sales | 0.9x | 9.4x | 3.4x | |
Upside (Analyst Target) | 63.9% | 48.4% | 44.9% | |
Fair Value Upside | Unlock | 10.1% | 6.3% | Unlock |