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Pro Research: Wall Street dives into Amgen's diverse biopharma strategies

EditorAhmed Abdulazez Abdulkadir
Published 01/21/2024, 08:42 AM
Updated 04/02/2024, 08:41 AM

Amgen Inc (NASDAQ:AMGN). continues to be a prominent force in the biopharmaceutical sector, focusing on developing innovative therapies for serious illnesses. The company's involvement in areas such as oncology, cardiovascular disease, bone health, neuroscience, nephrology, inflammation, rare diseases, and now, notably, in cardiovascular outcomes trials (CVOT) for Lp(a), a risk factor for cardiovascular disease, showcases its commitment to addressing a wide spectrum of medical challenges.

Company Overview and Performance

Amgen's portfolio, which includes assets like Tarlatamab, AMG-193, BLINCYTO, Xaluritamig, LUMAKRAS, Bemarituzumab, Tepezza, Krystexxa, Uplizna, and the recently highlighted Olpasiran for Lp(a) reduction, has solidified its leadership in various therapeutic areas. The company's pipeline progress, especially with the upcoming completion of CVOT enrollment for Olpasiran, is poised to make significant contributions to the treatment of cardiovascular diseases.

The financial results of Amgen have shown resilience, with the company's updated FY23 guidance reflecting the positive impact of strategic acquisitions like Horizon and a clear pipeline strategy for the future. Earnings for Q3 2023 demonstrated the company's ability to offset some underperformance in recent launches with a strong base business.

Market Trends and Competitive Landscape

Amgen's strategic focus has expanded to include the Lp(a) market, with its asset Olpasiran expected to validate Lp(a)/CVD causation and potentially tap into a market estimated to reach over $20 billion. Despite the high costs associated with CVOT studies and competition from other companies in the Lp(a) space, Amgen's active involvement in four active CVOT studies demonstrates its high conviction in this area of therapy.

Additionally, Amgen's presence at the Obesity Summit indicates a strategic interest in the treatment of obesity, aligning with current healthcare trends and addressing chronic illnesses associated with obesity.

Financial Outlook and Projections

Analysts from BMO Capital Markets have maintained an Outperform rating for Amgen with a price target of $343.00, reflecting a total return potential of 30.9%. Revenue guidance for FY23 has been raised, and estimates for FY24 EPS and revenue have been revised upwards, signaling confidence in the company's growth trajectory. The Horizon transaction and the company's involvement in CVOT studies for Lp(a) are expected to be key drivers of future value.

Bear Case

Is Amgen's base business decline a cause for concern?

While Amgen's pipeline and acquisitions are robust, concerns about the long-term stability of its revenue persist due to potential declines in its base business. The competition within the I&I franchise remains intense, and the company's significant size poses challenges for organic growth. However, management's conservative outlook may provide opportunities for positive surprises in the future.

Will regulatory challenges impede Amgen's progress?

Regulatory hurdles continue to be a concern for Amgen, especially with the FDA's scrutiny of new drug applications. Nevertheless, the company's proactive engagement with regulatory agencies and strategic handling of the Horizon integration and the IRS transfer pricing case could mitigate these risks.

Bull Case

Can Amgen capitalize on its diversified oncology portfolio and cardiovascular focus?

Analysts are optimistic about Amgen's diversified portfolio, including its oncology assets and Olpasiran's potential in the cardiovascular space. The company's strategic acquisitions and pipeline developments are expected to drive future growth, especially with the high market potential for Lp(a) targeting drugs.

Will Amgen's strategic acquisitions and involvement in obesity treatment discussions drive future growth?

The Horizon acquisition and Amgen's active role in obesity treatment discussions at the Obesity Summit are seen as strategic moves that could contribute significantly to the company's future growth.

SWOT Analysis


- Diversified portfolio with progress in oncology, cardiovascular, and obesity treatment areas.

- Strong pipeline with potential in rare diseases and the addition of Olpasiran for Lp(a) reduction.

- Strategic acquisitions and involvement in high-conviction CVOT studies.


- Potential decline in base business and challenges in achieving significant organic growth.

- Regulatory hurdles and the necessity of successful integration of acquisitions.

- Competition within the I&I franchise and the Lp(a) space.


- Entry into the cardiovascular and metabolic spaces with promising pipeline assets like Olpasiran.

- Increased revenue guidance and raised FY24 EPS and revenue estimates.

- Active engagement in evolving therapeutic approaches to obesity.


- High costs and risks associated with CVOT studies and regulatory approvals.

- Intense competition in the biopharmaceutical sector and the Lp(a) market.

- Potential revenue erosion if new products and acquisitions do not compensate for base business declines.

Analysts Targets

- BMO Capital Markets: Outperform rating with a price target of $343.00 (March 18, 2024).

- Barclays Capital Inc.: Underweight rating with a price target of $230.00 (February 23, 2024).

- Truist Securities: Buy rating with a price target of $320.00 (November 2, 2023).

In conclusion, Amgen's strategic focus on innovative therapies, including its recent foray into cardiovascular and obesity treatments, combined with its diversified portfolio and pipeline prospects, presents a complex yet promising picture for investors. While regulatory challenges and competition are notable concerns, the company's acquisitions and research initiatives could lead to significant growth. The analyses, spanning from October 2023 to March 2024, offer a comprehensive view of Amgen's standing in the biopharmaceutical industry.

InvestingPro Insights

As Amgen Inc. continues to make strides in the biopharmaceutical industry, its financial health and stock performance are key indicators for investors. According to recent data from InvestingPro, Amgen boasts a robust market capitalization of $151.69 billion, underscoring its significant presence in the market. The company's Price/Earnings (P/E) ratio stands at 22.46, indicating investor expectations of future earnings growth, though it is worth noting that the P/E ratio adjusted for the last twelve months as of Q4 2023 is higher at 27.64. This suggests that while the company is trading at a premium based on earnings, investors may be factoring in Amgen's long-term potential and its history of consistent dividend payments for 14 consecutive years.

InvestingPro Tips highlight that Amgen has been a stable dividend payer, which is an attractive feature for income-focused investors. The company's dividend yield as of recent data is 3.18%, with a dividend growth of 5.63% in the last twelve months as of Q4 2023. Additionally, Amgen's stock generally trades with low price volatility, which could appeal to investors seeking a less turbulent investment experience.

For investors seeking more in-depth analysis, InvestingPro offers additional tips on Amgen, including insights into the company's valuation metrics like the high Price/Book multiple of 24.34 and predictions of profitability for the current year. With more tips available on InvestingPro, investors can gain a comprehensive understanding of Amgen's financial standing and make more informed decisions. There are 8 additional InvestingPro Tips listed on, providing a wealth of information for anyone closely following the company's performance.

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

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