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Moderna's next-gen COVID-19 vaccine shows higher immune response

EditorAhmed Abdulazez Abdulkadir
Published 03/26/2024, 07:20 AM
©  Reuters

CAMBRIDGE, MA - Moderna , Inc. (NASDAQ:MRNA) reported on Monday that its next-generation COVID-19 vaccine, mRNA-1283, has surpassed the primary endpoints in a Phase 3 trial, indicating a stronger immune response than its predecessor, Spikevax® (mRNA-1273.222). The announcement is based on a press release statement from the company.

The trial, named NextCOVE, involved around 11,400 participants aged 12 and older across the United States, United Kingdom, and Canada. The study found that mRNA-1283 generated a higher immune response against both the Omicron BA.4/BA.5 and the original SARS-CoV-2 virus strains, particularly in individuals over 65 years of age, a demographic at greater risk for severe COVID-19 outcomes.

Common side effects included injection site pain, headache, fatigue, myalgia, and chills, aligning with the safety profile of Moderna's approved COVID-19 vaccines.

Moderna's CEO, Stéphane Bancel, expressed confidence in the vaccine's potential, highlighting its role in the company's combined flu and COVID-19 vaccine strategy, mRNA-1083. The improved storage and shelf life of mRNA-1283 could also benefit healthcare providers and expand access to the vaccine.

Further details of the Phase 3 data will be presented at Moderna's upcoming Vaccines Day on March 27 and at subsequent scientific conferences.

Moderna, a pioneer in mRNA technology, has been at the forefront of developing vaccines and therapeutics for various diseases, including one of the earliest COVID-19 vaccines.

The company continues to leverage its mRNA platform to address infectious diseases, immuno-oncology, rare diseases, and autoimmune conditions.

InvestingPro Insights

As Moderna continues to innovate with its mRNA technology, the financial metrics and management strategies provide a window into the company's position and future prospects. According to InvestingPro data, Moderna holds a market capitalization of $42.26 billion, reflecting its significant presence in the biotechnology sector. Despite a challenging period with a sharp revenue decline of -64.45% over the last twelve months as of Q4 2023, Moderna's management has been proactively responding by aggressively buying back shares, a move that can signal confidence in the company's value.

Furthermore, Moderna's balance sheet strength is underscored by a notable financial strategy: the company holds more cash than debt. This solid financial footing, as highlighted by InvestingPro Tips, may provide the flexibility required to navigate through periods of market volatility and invest in research and development. Additionally, with a significant return of 17.4% over the last month, investors have shown renewed interest in Moderna's stock, potentially buoyed by promising developments such as the next-generation COVID-19 vaccine, mRNA-1283.

While analysts have revised their earnings downwards for the upcoming period and anticipate a sales decline in the current year, Moderna's strategic approach, including its vaccine pipeline, could play a crucial role in driving future growth. Investors interested in deeper analysis can find a comprehensive list of 13 additional InvestingPro Tips for Moderna at https://www.investing.com/pro/MRNA. For those seeking to take their investment research to the next level, use coupon code PRONEWS24 to get an additional 10% off a yearly or biyearly Pro and Pro+ subscription.

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

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