Protagonist Therapeutics, Inc., a biopharmaceutical company, develops peptide-based drugs for hematology and blood disorders, and inflammatory and immunomodulatory diseases. It is developing Rusfertide (PTG-300), an injectable hepcidin mimetic that completed phase 2 clinical trials for the treatment of polycythemia vera and other blood disorders; and JNJ-2113, an orally delivered investigational drug to block biological pathways that completed phase 2b clinical trials for the treatment of moderate-to-severe plaque psoriasis; and PN-943, an orally delivered, gut-restricted alpha 4 beta 7 specific integrin antagonist completed a phase 2 clinical trials in patients with moderate to severe ulcerative colitis. The company has a license and collaboration agreement with Takeda to commercialize rusfertide; and JNJ Innovative Medicines to co-develop Interleukin-23 receptor antagonist compound JNJ-2113. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.
Financial Outlook | With $595 million in cash and an average analyst price target of $45.75, Protagonist is well-positioned to fund operations through 2027 and pursue growth opportunities |
Pipeline Expansion | PN-881, a potent IL-17 antagonist, showcases Protagonist's innovation in peptide-based drugs, with plans for Phase 1 study initiation in Q4 2025 |
Strategic Partnerships | Collaborations with Takeda and Johnson & Johnson bolster Protagonist's pipeline, providing external validation and financial support for key drug candidates |
Clinical Milestones | Protagonist's rusfertide enters Phase 3 trials for polycythemia vera, with efficacy data expected in Q1 2025, potentially paving the way for market entry |
Metrics to compare | PTGX | Sector Sector - Average of metrics from a broad group of related Healthcare sector companies | Relationship RelationshipPTGXPeersSector | |
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P/E Ratio | 14.7x | −2.1x | −0.7x | |
PEG Ratio | 0.07 | 0.03 | 0.00 | |
Price / Book | 4.7x | 1.3x | 2.6x | |
Price / LTM Sales | 7.7x | 19.5x | 3.2x | |
Upside (Analyst Target) | 37.9% | 378.3% | 47.0% | |
Fair Value Upside | Unlock | 10.0% | 7.5% | Unlock |