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Enrollment completed in Seattle Genetics and Takeda's late-stage study of Adcetris in certain type of T-cell lymphoma

Published 11/08/2016, 09:26 AM
Enrollment completed in Seattle Genetics and Takeda's late-stage study of Adcetris in certain type of T-cell lymphoma
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  • A total of 452 patients have been enrolled in a global Phase 3 clinical trial, ECHELON-2, assessing Seattle Genetics (NASDAQ:SGEN) and Takeda Pharmaceutical Company's (OTCPK:TKPHF)(OTCPK:TKPYY) ADCETRIS (brentuximab vedotin), in combination with chemotherapy, in treatment-naive patients with CD30-positive mature T-cell lymphoma (MTCL).
  • Participants will be randomized 1:1 to receive either ADCETRIS plus the chemo regimen CHP (cyclophosphamide, doxorubicin, prednisone) or the chemo regiment CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone), the standard-of-care frontline treatment for MTCL. The primary endpoint is progression-free survival. According to ClinicalTrials.gov, the estimated final data collection date for the primary endpoint is December 2017. The estimated study completion date is December 2019.
  • ADCETRIS, an antibody-drug conjugate, is being co-developed by the two companies. Seattle Genetics has commercialization rights in the U.S. and Canada and Takeda has commercialization rights elsewhere. It is currently approved in the U.S. for the treatment of certain types of lymphoma.

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