BOSTON & LONDON - Centessa Pharmaceuticals plc (NASDAQ:CNTA) announced today the presentation of new data from its ongoing Phase 2a study of SerpinPC, a treatment candidate for hemophilia. The findings, which cover an additional 52 weeks of continuous treatment, were revealed at the 17th Annual Congress of the European Association for Haemophilia and Allied Disorders (EAHAD) in Frankfurt, Germany.
SerpinPC, a subcutaneously administered novel inhibitor of activated protein C (APC), is currently in registrational studies for the treatment of hemophilia B, with or without inhibitors. The data presented stems from the third year (Part 5) of the study, building on results previously shared at the 65th American Society of Hematology (ASH) Annual Meeting.
Saurabh Saha MD PhD, Chief Executive Officer of Centessa, expressed optimism about the therapeutic potential of SerpinPC, noting the data reinforces the company's confidence in the treatment's novel mechanism of action. The Phase 2a study (AP-0101) is designed to assess the safety, tolerability, pharmacokinetics, and efficacy of SerpinPC in male participants with severe hemophilia.
The U.S. Food and Drug Administration (FDA) has granted Fast Track designation to SerpinPC for hemophilia B treatment. However, it is important to note that SerpinPC is an investigational agent and has not been approved by the FDA or any other regulatory authority.
The registrational program for SerpinPC includes various clinical studies such as PRESent-5, an observational feeder study, and interventional studies PRESent-2 and PRESent-3, details of which can be found on the clinicaltrials.gov website.
This news is based on a press release statement.
InvestingPro Insights
As Centessa Pharmaceuticals (NASDAQ:CNTA) continues to make strides in the development of SerpinPC for hemophilia treatment, the company's financial health and market performance remain critical for investors. According to recent data, Centessa holds a market capitalization of approximately $728.31 million. Despite challenges, the company has shown a notable high return over the last year, with a 104.95% increase in price total return. This performance is also reflected in the strong 18.79% price total return over the last three months.
InvestingPro Tips suggest that Centessa has more cash than debt on its balance sheet, which is a positive sign for the company's financial stability. Additionally, two analysts have revised their earnings upwards for the upcoming period, indicating potential confidence in Centessa's future performance. However, it is important for investors to consider that analysts do not anticipate the company will be profitable this year, and the company is quickly burning through cash. Centessa's liquid assets exceed short-term obligations, which may provide some assurance regarding the company's ability to meet its immediate financial commitments.
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