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Madrigal Pharmaceuticals announces positive outcome from DSMB safety review and completes enrollment of Phase 2 study of MGL-3196 in patients with HeFH

Published 09/19/2017, 08:17 AM
© Reuters.  Madrigal Pharmaceuticals announces positive outcome from DSMB safety review and completes enrollment of Phase 2 study of MGL-3196 in patients with HeFH
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  • Madrigal Pharmaceuticals (NASDAQ:MDGL) announces that the Company’s independent Data Safety Monitoring Board held its second prespecified meeting to evaluate both the heterozygous familial hypercholesterolemia (HeFH) and non-alcoholic steatohepatitis Phase 2 clinical trials and recommended that both studies continue unchanged.
  • The primary endpoint of the Phase 2 HeFH study is reduction of LDL cholesterol, with secondary endpoints including reductions in triglycerides, Lp(a), and ApoB, as well as safety.
  • Madrigal also announces that the Phase 2 study of MGL-3196 for the treatment of HeFH has enrolled 113 patients, exceeding the target of 105 patients and will continue enrollment for the next several days. Top-line results are expected in early 2018.
  • Now read: Arbutus Biopharma: Updates To Thesis

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