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Jefferies downgrades Instil Bio stock, cites clinical development halt

EditorEmilio Ghigini
Published 04/12/2024, 04:25 AM
Updated 04/12/2024, 04:25 AM

On Friday, Instil Bio Inc (NASDAQ:TIL) stock saw a shift in its rating as Jefferies downgraded it from Buy to Hold, while simultaneously increasing its price target to $11 from the previous $5. The adjustment comes as Instil Bio undergoes significant changes, including a strategic restructuring and the halt of clinical development for its ITIL-306 (FRαTIL) program.

The company is now focusing on a collaboration with a China-based partner to explore manufacturing feasibility for '306, with the potential for initiating investigator-initiated trials (IIT) in non-small cell lung cancer (NSCLC). With a year-end 2023 cash position of $175 million, Instil Bio is actively seeking to in-license or acquire novel candidates to address diseases with significant unmet medical needs.

The updated model from Jefferies reflects the discontinuation of the '306 program and a reverse stock split. The firm's decision to downgrade to Hold is based on waiting for future updates from Instil Bio. The new price target of $11 reflects the analysts' revised expectations for the company's stock performance.

The developments at Instil Bio signal a pivot in strategy as the company adapts to the discontinuation of one of its key clinical programs. The collaboration in China and the search for new opportunities highlight Instil Bio's efforts to reposition itself within the biotechnology industry.

Investors and market observers will be closely monitoring Instil Bio's progress as it navigates these changes and seeks to enhance its portfolio. The increase in the price target suggests a level of confidence in the company's ability to recover and find new pathways for growth despite the recent challenges.

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InvestingPro Insights

Instil Bio Inc's (NASDAQ:TIL) recent downgrade by Jefferies to a Hold rating, despite an increased price target, reflects a cautious optimism that aligns with certain financial metrics and analyst insights from InvestingPro. Notably, Instil Bio holds more cash than debt, which is a reassuring sign of financial stability for investors, especially as the company seeks to acquire new assets and forge strategic partnerships. Additionally, the company's liquid assets exceed its short-term obligations, providing a buffer for operational flexibility.

On the flip side, the company is rapidly depleting its cash reserves and has weak gross profit margins, which could be a concern as it discontinues its ITIL-306 program and embarks on new ventures. Moreover, analysts do not expect Instil Bio to be profitable this year, and the company has not been profitable over the last twelve months. These factors may contribute to the Hold rating, as investors might be wary of the company's short-term financial health and its ability to generate profit in the near future.

Despite these challenges, Instil Bio has experienced a strong return over the last three months, with a 43.35% price total return, and an even larger uptick over the last six months at 49.0%. This performance suggests a level of market confidence that could be buoyed by the company's strategic pivot and its potential for new growth avenues in the biotechnology industry.

For investors looking for a deeper dive into Instil Bio's financial health and future prospects, InvestingPro offers additional tips and insights. Utilize the coupon code PRONEWS24 to get an extra 10% off a yearly or biyearly Pro and Pro+ subscription, and gain access to a wealth of data and analytics that can inform smarter investment decisions. There are 7 more InvestingPro Tips available for Instil Bio, which can provide further guidance on whether to hold, sell, or buy in light of the company's recent developments.

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This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

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