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South African variant can 'break through' Pfizer vaccine, Israeli study says

Stock MarketsApr 10, 2021 05:26PM ET
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3/3 © Reuters. FILE PHOTO: Nuns stand in a queue outside a newly-opened centre administering vaccinations against the coronavirus disease (COVID-19) in a neighbourhood with a high residency of foreign nationals, including migrant workers, in Tel Aviv 2/3

By Maayan Lubell

JERUSALEM (Reuters) - The coronavirus variant discovered in South Africa can "break through" Pfizer/BioNTech's COVID-19 vaccine to some extent, a real-world data study in Israel found, though its prevalence in the country is low and the research has not been peer reviewed.

The study, released on Saturday, compared almost 400 people who had tested positive for COVID-19, 14 days or more after they received one or two doses of the vaccine, against the same number of unvaccinated patients with the disease. It matched age and gender, among other characteristics.

The South African variant, B.1.351, was found to make up about 1% of all the COVID-19 cases across all the people studied, according to the study by Tel Aviv University and Israel's largest healthcare provider, Clalit.

But among patients who had received two doses of the vaccine, the variant's prevalence rate was eight times higher than those unvaccinated - 5.4% versus 0.7%.

This suggests the vaccine is less effective against the South African variant, compared with the original coronavirus and a variant first identified in Britain that has come to comprise nearly all COVID-19 cases in Israel, the researchers said.

"We found a disproportionately higher rate of the South African variant among people vaccinated with a second dose, compared to the unvaccinated group. This means that the South African variant is able, to some extent, to break through the vaccine's protection," said Tel Aviv University's Adi Stern.

The researchers cautioned, though, that the study only had a small sample size of people infected with the South African variant because of its rarity in Israel.

They also said the research was not intended to deduce overall vaccine effectiveness against any variant, since it only looked at people who had already tested positive for COVID-19, not at overall infection rates.

Pfizer (NYSE:PFE) and BioNTech could not be immediately reached for comment outside business hours.

The companies said on April 1 that their vaccine was around 91% effective at preventing COVID-19, citing updated trial data that included participants inoculated for up to six months.

In respect to the South African variant, they said that among a group of 800 study volunteers in South Africa, where B.1.351 is widespread, there were nine cases of COVID-19, all of which occurred among participants who got the placebo. Of those nine cases, six were among individuals infected with the South African variant.

Some previous studies have indicated that the Pfizer/BioNTech shot was less potent against the B.1.351 variant than against other variants of the coronavirus, but still offered a robust defence.

While the results of the study may cause concern, the low prevalence of the South African strain was encouraging, according to Stern.

"Even if the South African variant does break through the vaccine's protection, it has not spread widely through the population," said Stern, adding that the British variant may be "blocking" the spread of the South African strain.

Almost 53% of Israel's 9.3 million population has received both Pfizer doses. Israel has largely reopened its economy in recent weeks while the pandemic appears to be receding, with infection rates, severe illness and hospitalizations dropping sharply. About a third of Israelis are below the age of 16, which means they are still not eligible for the shot.

South African variant can 'break through' Pfizer vaccine, Israeli study says
 

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Comments (6)
James Sun
James Sun Apr 11, 2021 8:20AM ET
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Hum ...
Pat Mathieu
Pat Mathieu Apr 10, 2021 9:50PM ET
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Misleading Reuters article as usual. I guess it means their boss wants market down next week.
Eudon Hickey
Eudon Hickey Apr 10, 2021 9:42PM ET
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What a hoax all this covid stuff!!Follow the money abd it takes you to certain people(fauci and obama admin who sponsored the program up till 2014)So yes, the virus did come from the wuhan lab, but the money behind it was from Fauci/Obama
Mase Gumbo
Mase Gumbo Apr 10, 2021 9:42PM ET
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omg ...do you do standup? hilarious
Ankit Jain
Ankit Jain Apr 10, 2021 9:20PM ET
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one of the best new hopefully it can break through moderna also
Randy Randy
randy00 Apr 10, 2021 8:08PM ET
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Gonna have to turn comments off this site.
Stan Deviation
Stan Deviation Apr 10, 2021 7:49PM ET
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Holy bot wars...
 
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