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J&J to discontinue HIV vaccine trial
Published Jan 18, 2023 08:43AM ET
Updated Jan 18, 2023 11:33AM ET
© Reuters. FILE PHOTO: People pose with syringe with needle in front of displayed Johnson & Johnson logo in this illustration taken, December 11, 2021. REUTERS/Dado Ruvic/Illustration
By Leroy Leo
(Reuters) -Johnson & Johnson said on Wednesday that it was pulling the plug on a late-stage global trial of an HIV vaccine after the shot was found ineffective at preventing infections.
The trial's failure marks yet another setback in the search for a vaccine against a virus known to mutate rapidly and find unique ways to evade the immune system, and comes more than a year after another of J&J (NYSE:JNJ)'s HIV vaccine failed a study.
"It's not the outcome we had hoped for, unfortunately," said a spokesperson for the National Institute of Allergy and Infectious Diseases (NIAID), a J&J partner in the trial.
"The development of a safe and effective HIV vaccine has been a considerable scientific challenge, but we will learn from this study and continue forward."
The trial involved administering two different types of a shot, which uses a cold-causing virus to deliver the genetic code of HIV, spread over four vaccination visits in a year. J&J used similar technology for its COVID-19 vaccine.
The study, which began in 2019, was conducted at over 50 sites and included about 3,900 gay men and transgender people - groups that are considered vulnerable to the infection.
Another J&J partner, the HIV Vaccine Trials Network (HVTN), said the shot was being tested only on individuals who did not accept pre-exposure prophylaxis, a treatment to prevent infections.In 2021, around 650,000 people died from HIV-related causes while 1.5 million people acquired the infection, according to the World Health Organization.Various HIV vaccine candidates, including from Moderna (NASDAQ:MRNA) Inc, HVTN and NIAID are currently under trial.
While no HIV vaccine has successfully cleared trials so far, some drugs are used in high-risk groups and patients.
Shares of J&J were down 1.3% at $170.14 in morning trade.
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