Breaking News
0
Ad-Free Version. Upgrade your Investing.com experience. Save up to 40% More details

In boost for COVID-19 battle, Pfizer vaccine found 94% effective in real world

CoronavirusFeb 24, 2021 05:31PM ET
Saved. See Saved Items.
This article has already been saved in your Saved Items
 
2/2 © Reuters. FILE PHOTO: Vials labelled "COVID-19 Coronavirus Vaccine" and a syringe are seen in front of the Pfizer logo in this illustration 2/2

By Maayan Lubell and Ari Rabinovitch

JERUSALEM (Reuters) - The first big real-world study of the Pfizer/BioNTech vaccine to be independently reviewed shows the shot is highly effective at preventing COVID-19, in a potentially landmark moment for countries desperate to end lockdowns and reopen economies.

Up until now, most data on the efficacy of COVID-19 vaccines has come under controlled conditions in clinical trials, leaving an element of uncertainty over how results would translate into the real world with its unpredictable variables.

The research in Israel - two months into one of the world's fastest rollouts, providing a rich source of data - showed two doses of the Pfizer (NYSE:PFE) shot cut symptomatic COVID-19 cases by 94% across all age groups, and severe illnesses by nearly as much.

The study of about 1.2 million people also showed a single shot was 57% effective in protecting against symptomatic infections after two weeks, according to the data published and peer-reviewed in the New England Journal of Medicine on Wednesday.

The results of the study for the Clalit Research Institute were close to those in clinical trials last year which found two doses were found to be 95% effective.

"We were surprised because we expected that in the real-world setting, where cold chain is not maintained perfectly and the population is older and sicker, that you will not get as good results as you got in the controlled clinical trials," senior study author Ran Balicer told Reuters. "But we did and the vaccine worked as well in the real world."

"We have shown the vaccine to be as effective in very different sub-groups, in the young and in the old in those with no co-morbidities and in those with few co-morbidities," he added.

The study also suggests the vaccine, developed by U.S drugmaker Pfizer and Germany's BioNTech, is effective against the coronavirus variant first identified in the UK. Researchers said they could not provide a specific level of efficacy, but the variant was the dominant version of the virus in Israel at the time of the study.

The research did not shed light on how the Pfizer shot will fare against another variant, now dominant in South Africa, that has been shown to reduce the efficacy of other vaccines.

'THIS IS MORE GREAT NEWS'

Of the nine million people in Israel, a nation with universal healthcare, nearly half have received a first dose, and a third have received both doses since the rollout began on Dec. 19.

This made the country a prime location for a real-world study into the vaccine's ability to stem the pandemic, along with its advanced data capabilities.

The study examined about 600,000 vaccinated people against the same sized control group of unvaccinated people. Researchers at Harvard T.H. Chan School of Public Health, Harvard Medical School and Boston Children's Hospital also collaborated.

"This is more great news, confirming that the vaccine is around 90% effective at preventing documented infection of any degree of severity from 7 days after the second dose," said Peter English, a British government consultant in communicable disease control.

"Previous recently studied papers from Israel were observational studies. This one used an experimental design known as a case-control study ... giving greater confidence that differences between the groups are due to their vaccination status, and not to some other factor."

The study published on Wednesday was the first analysis of a national COVID-19 vaccination strategy to be peer-reviewed. It also offered a more detailed look at how the vaccine was faring at weekly intervals, while matching people who received the shot to unvaccinated individuals with similar medical histories, sex, age and geographical characteristics.

Other research centres in Israel, including the Weizmann Institute of Science and the Israel Institute of Technology have shared several studies in recent weeks that show the vaccine to be effective.

At least three studies out of Israel have also suggested the vaccine can reduce coronavirus transmission, but the researchers have cautioned that wider studies must be conducted in order to establish clear-cut conclusions.

GOT YOUR IMMUNITY PASS?

The Weizmann Institute's latest data shows a dramatic drop in illness - which began this month with the first age group vaccinated, the over-60s - has now extended to the two subsequent groups to have completed both doses.

As infections have fallen in Israel, the country has eased its third national lockdown and reopened swathes of its economy including malls, shops, schools and many workplaces in the past two weeks.

Recreational venues such as theatres, gyms and hotels opened on Sunday, but are open only to those deemed immune - holders of a "Green Pass", a health ministry document available for download only by people seven days after their second dose or people who have recovered from COVID-19.

On Wednesday, Tel Aviv held one of the country's first live concerts after months of gatherings being banned under coronavirus restrictions.

"This is so exciting, we are really so happy to be here today. It's unbelievable after one year of staying at home, it's great to be out to see some culture," said 60-year-old Gabi Shamir as she took her seat at the open-air show.

Still, the vaccine's efficacy does not mean the country will be pandemic free any time soon. Like elsewhere in the world, a large proportion of the population are under 16 - about a third in Israel - meaning that they cannot yet get vaccinated as there have not been clinical trial results for children.

"This is definitely not the end of the pandemic," said Eran Kopel, an epidemiologist at Tel Aviv University. "Once there is a safe vaccine for the children in Israel and all over the world we can then start to say that we could be approaching herd immunity."

(Adittional reporting by Rami Amichay in Tel Aviv and Kate Kelland in London; Writing by Maayan Lubell; Editing by Pravin Char)

In boost for COVID-19 battle, Pfizer vaccine found 94% effective in real world
 

Related Articles

Add a Comment

Comment Guidelines

We encourage you to use comments to engage with users, share your perspective and ask questions of authors and each other. However, in order to maintain the high level of discourse we’ve all come to value and expect, please keep the following criteria in mind: 

  • Enrich the conversation
  • Stay focused and on track. Only post material that’s relevant to the topic being discussed.
  • Be respectful. Even negative opinions can be framed positively and diplomatically.
  •  Use standard writing style. Include punctuation and upper and lower cases.
  • NOTE: Spam and/or promotional messages and links within a comment will be removed
  • Avoid profanity, slander or personal attacks directed at an author or another user.
  • Don’t Monopolize the Conversation. We appreciate passion and conviction, but we also believe strongly in giving everyone a chance to air their thoughts. Therefore, in addition to civil interaction, we expect commenters to offer their opinions succinctly and thoughtfully, but not so repeatedly that others are annoyed or offended. If we receive complaints about individuals who take over a thread or forum, we reserve the right to ban them from the site, without recourse.
  • Only English comments will be allowed.

Perpetrators of spam or abuse will be deleted from the site and prohibited from future registration at Investing.com’s discretion.

Write your thoughts here
 
Are you sure you want to delete this chart?
 
Post
Post also to:
 
Replace the attached chart with a new chart ?
1000
Your ability to comment is currently suspended due to negative user reports. Your status will be reviewed by our moderators.
Please wait a minute before you try to comment again.
Thanks for your comment. Please note that all comments are pending until approved by our moderators. It may therefore take some time before it appears on our website.
 
Are you sure you want to delete this chart?
 
Post
 
Replace the attached chart with a new chart ?
1000
Your ability to comment is currently suspended due to negative user reports. Your status will be reviewed by our moderators.
Please wait a minute before you try to comment again.
Add Chart to Comment
Confirm Block

Are you sure you want to block %USER_NAME%?

By doing so, you and %USER_NAME% will not be able to see any of each other's Investing.com's posts.

%USER_NAME% was successfully added to your Block List

Since you’ve just unblocked this person, you must wait 48 hours before renewing the block.

Report this comment

I feel that this comment is:

Comment flagged

Thank You!

Your report has been sent to our moderators for review
Disclaimer: Fusion Media would like to remind you that the data contained in this website is not necessarily real-time nor accurate. All CFDs (stocks, indexes, futures) and Forex prices are not provided by exchanges but rather by market makers, and so prices may not be accurate and may differ from the actual market price, meaning prices are indicative and not appropriate for trading purposes. Therefore Fusion Media doesn`t bear any responsibility for any trading losses you might incur as a result of using this data.

Fusion Media or anyone involved with Fusion Media will not accept any liability for loss or damage as a result of reliance on the information including data, quotes, charts and buy/sell signals contained within this website. Please be fully informed regarding the risks and costs associated with trading the financial markets, it is one of the riskiest investment forms possible.
Continue with Google
or
Sign up with Email