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Senti Biosciences, Inc. operates as a preclinical biotechnology company that develops next-generation cell and gene therapies engineered with its gene circuit platform technologies for various diseases. Its lead product candidates utilize allogeneic chimeric antigen receptor natural killer (CAR-NK) cells outfitted with its gene circuit technologies in various oncology indications. The company product candidates include SENTI-202, a Logic Gated OR+NOT off-the-shelf CAR-NK cell therapy designed to target and eliminate cancer cells while sparing the healthy bone marrow; and SENTI-301A for the treatment of hepatocellular carcinoma. It also develops SENTI-401, a Logic Gated off-the-shelf CAR-NK cell therapy designed to target and eliminate colorectal cancer/CRC cells. In addition, the company develops Tumor-Associated Antigen and Protective Antigen Paired Discovery Platform to select and validate NOT GATE antigen candidates and identify tumor-associated antigens in cancer cells. The company has a strategic collaboration with Celest Therapeutics (Shanghai) Co. Ltd for the clinical development of SENTI-301A to treat solid tumors. Senti Biosciences, Inc. was incorporated in 2016 and is headquartered in South San Francisco, California.
Name | Age | Since | Title |
---|---|---|---|
Susan D. Berland | 68 | 2021 | Senior Financial Executive & Independent Director |
Martin Fussenegger | - | - | Member of Scientific Advisory Board |
Michael D. Varney | 65 | 2021 | Member of Scientific Advisory Board |
James J. Collins | 57 | 2021 | Scientific Co-Founder, Chairperson of Scientific Advisory Board & Independent Director |
Robin G. Taylor | - | 2021 | Member of Scientific Advisory Board |
Michael Andreeff | - | - | Member of Scientific Advisory Board |
Lawrence Fong | - | - | Member of Scientific Advisory Board |
Edward T. Mathers | 63 | 2016 | Independent Director |
Wilson Wong | - | - | Scientific Co-Founder & Member of Scientific Advisory Board |
Michael Kalos | - | 2021 | Member of Scientific Advisory Board |
Timothy K. Lu | 42 | 2016 | Co-Founder, CEO, President & Director |
Omid C. Farokhzad | 54 | 2022 | Independent Director |
Ahmad Khalil | - | - | Member of Scientific Advisory Board |
Brenda G. Cooperstone | 58 | 2019 | Independent Director |
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