- As expected, the European Commission approves Pfizer 's (NYSE:PFE) IBRANCE (palbociclib), in combination with an aromatase inhibitor [e.g., AstraZeneca's (NYSE:AZN) Arimidex (anastrozole)] for the treatment of women with hormone receptor-positive, human epidermal growth factor receptor-2-negative (HR+/HER2-) locally advanced or metastatic breast cancer. The approval also covers the use of IBRANCE in combination with fulvestrant (AZN's FASLODEX) who have received prior endocrine therapy.
- Palbociclib is an inhibitor of cyclin-dependent kinase (CDK) 4 and 6, downstream signaling pathways which lead to cellular proliferation. When combined with an antiestrogen, it inhibits the growth of breast cancer by interfering with these pathways and promoting the deterioration of cancer cells (senescence).
- The advisory committee CHMP adopted a positive opinion in mid-September backing approval.
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Pfizer's Ibrance OK'd in Europe for breast cancer
Published 11/10/2016, 07:35 AM
Updated 11/10/2016, 07:35 AM
Pfizer's Ibrance OK'd in Europe for breast cancer
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