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Opexa's Tcelna flunks mid-stage MS study; shares crater 68% premarket

Published 10/28/2016, 09:27 AM
Updated 10/28/2016, 09:27 AM
Opexa's Tcelna flunks mid-stage MS study; shares crater 68% premarket
  • Thinly traded nano cap Opexa Therapeutics plummets 68% premarket on robust volume in response to its announcement that a Phase 2b study, Abili-T, assessing Tcelna (imilecleucel-T) in patients with secondary progressive multiple sclerosis failed to meet the primary endpoint of a reduction in brain volume change (atrophy) nor the secondary endpoint of reduction in the rate of sustained disease progression. On the plus side, Tcelna was safe and well-tolerated.
  • The company will continue its analysis of the data and will consider cash preservation options.
  • Tcelna is a personalized T-cell immunotherapy that is specifically tailored to each patient's immune response profile to myelin, a white fatty substance that insulates nerve cells. Multiple sclerosis is characterized by damage to this insulation, called the myelin sheath.

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