During European morning trade, the dollar was higher against the euro, with EUR/USD shedding 0.27% to hit 1.3091.
The euro remained under pressure ahead of a critical auction of two and 10-year Spanish government bonds on Thursday, amid uncertainty over whether the government will be able to reduce one of the euro zone’s largest budget deficits in the face of a looming recession.
Meanwhile, concerns over Portugal’s economic health intensified after Prime Minister Pedro Passos Coelho said Wednesday there were "no guarantees" that the country would meet its commitment to return to the international capital markets before September 2013.
But the greenback was lower against the pound, with GBP/USD rising 0.35% to hit 1.5976.
The pound was boosted after official data showed that the number of people claiming unemployment benefits in the U.K. rose less-than-expected last month, while the unemployment rate ticked down unexpectedly.
Also Wednesday, the minutes of the Bank of England’s April meeting showed that just one policymaker voted in favor of additional monetary easing, after two of the nine member monetary policy committee favored additional stimulus in March.
Elsewhere, the greenback was sharply higher against the yen, with USD/JPY advancing 0.76% to hit 81.45 and posted solid gains against the Swiss franc, with USD/CHF rising 0.38% to hit 0.9187.
The greenback was mostly higher against its Canadian, Australian and New Zealand counterparts, with USD/CAD dipping 0.05% to hit 0.9896, AUD/USD inching down 0.08% to hit 1.0380 and NZD/USD shedding 0.18% to hit 0.8197.
The growth linked currencies remained supported after the International Monetary Fund boosted its global growth outlook to 3.5% from 3.3%, citing an improving U.S. economy.
The dollar index, which tracks the performance of the greenback versus a basket of six other major currencies, was up 0.29% at 79.93.
Later in the day, the U.S. was to release official data on crude oil stockpiles.